Every generation of wireless technology needs to bring new system capabilities to enable future-generation applications and services. The sixth-generation mobile system (6G) is no exception. This talk will provide an overview of the technology transformation from the communication-centric 4G/5G systems to the compute-centric 6G system. The speaker will explain the technical and business motivations for this technology transformation, the important new use cases and corresponding workload models, the enabling programmable networking and data-center computing technologies, the design considerations for sustainability, and the protection of privacy and security. The speaker will present a 6G cloud-native system framework based on a direct extension of the 5G service-based architecture, serving as the foundation for developing a 6G wide-area softwarized distributed cloud to enable next-generation intelligent sensing, machine learning, and machine inference capabilities. The speaker will share a number of important design and performance tradeoffs with the audience to trigger further discussions, to stimulate technical innovations and to bring the technology transformation from concept to reality.